M523 Pill: Side Effects, Use And Benefits – All Details

The M523 Pill consists of an oxycodone and acetaminophen component and is used to relieve pain severe enough to require opioid therapy and when other pain medications do not work well enough or cannot be tolerated (1).

To see how a drug works, it is necessary to look at the ingredients in the drug.

The active ingredients in M523 are listed below:

  • Oxycodone Hydrochloride
  • Acetaminophen
M523 Pill

What Is Oxycodone Hydrochloride?

Oxycodone Hydrochloride is a strong centrally acting pain reliever that belongs to a group of drugs called opioids.

Oxycodone Hydrochloride is used only to treat severe pain that can be adequately managed with opioid analgesics.

What Is Acetaminophen?

Acetaminophen (Paracetamol) is a drug that acts as a pain reliever and also has an antipyretic feature.

This medication works by blocking the production of chemicals in the body that cause pain and inflammation.

Paracetamol also reduces pain by blocking pain centers in the brain.

Paracetamol is often used to relieve symptoms of headaches, toothaches, menstrual cramps, muscle pain, arthritis, and the common cold.

It is also used to reduce fever. However, paracetamol should only be used as a symptomatic treatment for the treatment of fever caused by infection.

Other drugs should be used to treat the infection causing the fever.

Things To Consider Before Using M523 Pills

Do not use M523 pills if you have any of the conditions listed below:

  • If you are allergic to oxycodone hydrochloride or any of the other ingredients of the medicine
  • If you suffer from severe respiratory depression with too little oxygen in the blood (hypoxia) and/or too much carbon dioxide in the blood (hypercapnia)
  • If you suffer from severe chronic obstructive pulmonary disease (Chronic Bronchitis or Chronic Obstructive Pulmonary Disease), cor pulmonale (cardiac changes due to chronic overload in the pulmonary circulation) or acute, severe bronchial asthma
  • If you suffer from intestinal paralysis (intestinal obstruction) (paralytic ileus)
  • If you have sudden abdominal discomfort or if you suffer from delayed stomach emptying.
  • Other situations in which opioids should not be used

If you have any of the conditions listed below, contact your doctor before using M523 pills:

  • If you are old or weak
  • If you have severely impaired lung, liver or kidney function
  • If you suffer from myxedema (certain diseases of the thyroid gland), impaired function of the thyroid gland
  • If you have adrenal insufficiency
  • If you suffer from enlarged prostate (prostatic hypertrophy)
  • If you suffer from alcoholism or are suffering from alcohol withdrawal
  • If you have a known addiction to opioids (chemicals that act in the body like morphine)
  • If you have pancreatic inflammation (pancreatitis)
  • If there is an increase in brain pressure
  • If you have a circulatory disorder
  • If you have disease in the bile duct or ureter (bile colic)
  • If you suffer from low blood pressure or decreased blood volume
  • if you have epilepsy or a predisposition to seizures (a condition that lowers the seizure threshold, such as a trauma to your brain, an inflammatory condition, or a stroke)
  • If you are using a group of drugs used to treat depression (MAO inhibitors, eg moclobemide)
  • if you have recently had bowel or abdominal surgery
  • If you have inflammatory bowel disease

This drug has the potential for primary addiction.

With prolonged use of this drug, tolerance to the effects may develop and gradually higher doses may be required to maintain pain control.

Chronic use of this drug may cause physical dependence and withdrawal syndrome may occur upon abrupt discontinuation.

When a patient no longer needs treatment with oxycodone hydrochloride, a gradual reduction of the dose is recommended to prevent withdrawal symptoms.

The risk of development of physical or psychological dependence is markedly reduced when used as directed in patients suffering from chronic pain and needs to be weighed against potential benefit.

Please discuss this with your doctor.

Rarely, a state of increased sensitivity to pain that does not respond to an increase in dose may develop.

If this occurs, your doctor will lower your dose or refer you to an alternative opioid pain reliever.

It is not recommended to use M523 pills before the operation or within 24 hours after the operation.

M523 pills should be used with particular caution in patients with past or current alcohol and drug abuse.

Drinking alcohol while taking M523 pills can make you feel more sleepy or increase the risk of serious side effects such as shallow breathing and loss of consciousness, including the risk of stopping breathing.

It is recommended not to drink alcohol while taking M523 pills.

Abusive intravenous administration of oral dosage forms can cause serious effects that can be fatal.

Concomitant use of this drug and benzodiazepine-type drugs (eg alprazolam, diazepam, lorazepam) may cause drowsiness, respiratory depression, coma and death.

When these drugs need to be used together, they should be used at the lowest dose and the treatment period should be kept as short as possible.

Patients should be closely monitored for signs of somnolence and respiratory depression.

M523 pills may affect the hormonal system (including the hypothalamic-pituitary-adrenal or gonadal axes).

Some changes can be observed, including increases in milk hormones, decreases in blood cortisol and male hormone levels.

If these warnings apply to you, even at any time in the past, please consult your doctor.

How To Use the M523 Pills?

The usual dose for M523 pills is 1 tablet orally every 6 hours as needed for pain.

It should not be used more than 6 tablets in 24 hours.

It should be noted that M523 pills should only be consumed as often as prescribed by doctors.

Therefore, if the dose recommended by your doctor is not the same as the dose below, please use the dose recommended by your doctor, not the dose recommendation in this article.

Pregnancy And Breastfeeding

If you are pregnant, you should avoid using the M523 pill unless your doctor recommends it.

This medicine crosses the placenta and enters the baby’s bloodstream.

Long-term use of M523 pills during pregnancy may cause withdrawal symptoms in newborns.

Babies born to mothers who used oxycodone in the last 3-4 weeks before delivery should be monitored for respiratory depression.

Use of this drug during childbearing may cause severe respiratory depression in the newborn.

This medicine should only be used during pregnancy if the benefit outweighs the potential risk to the baby.

If you become pregnant or plan to become pregnant during treatment, contact your doctor.

Oxycodone has no interactions with contraceptives.

If you realize that you are pregnant during your treatment, consult your doctor or pharmacist immediately.

You should not use M523 pills while breastfeeding because oxycodone can pass into breast milk and may cause breathing problems in the newborn.

What Are The Side Effects Of M523 Pills?

Like all medicines, this medicine may have side effects in people who are sensitive to its ingredients.

If any of the following occur, stop using this medicine and tell your doctor immediately or go to the nearest hospital emergency department.

Respiratory depression (suppression) is the most prominent risk induced by opioids and occurs most frequently in the elderly or debilitated patients.

Consequently, opioids can cause severe reductions in blood pressure in predisposed patients.

In addition, this drug may cause constriction of the pupils, bronchial spasm (contraction of the bronchi), spasm of the smooth muscles (contraction) and suppression of the cough reflex.

These are all very serious side effects.

If you have one of these, you may need emergency medical attention or hospitalization.

Very common side effects are listed below:

  • Sedation (from tiredness to drowsiness)
  • Dizziness
  • Headache
  • Constipation
  • Nausea
  • Vomiting
  • Itching

Common side effects are listed below:

  • Loss of appetite
  • Many psychological side effects: Mood changes (e.g. general fear, depression) Changes in activity (increased sedation, sometimes accompanied by fatigue, sometimes with irritability and sleep disturbances) Performance changes (thought disturbance, confusion (mindfulness))
  • Flicker
  • Wheezing, shortness of breath, hiccups, bronchospasm (contraction of the bronchi)
  • Dry mouth, stomach pain, diarrhea, indigestion
  • Rash, increased sweating
  • increased urge to urinate
  • feeling weak (asthenia)

Uncommon side effects are listed below:

  • allergic reactions
  • Abnormal production of antidiuretic hormone (a type of hormone secreted from an area of the brain)
  • Lack of water in the body (dehydration)
  • Self-alienation and changes in perception such as hearing, seeing or feeling things that are not there (hallucinations), decreased sexual desire, restlessness, excessive emotional behavior, feeling of extreme happiness, drug addiction
  • Increased or decreased muscle tone, coordination disorders, involuntary muscle spasms, seizures, especially in patients with epilepsy or predisposition to seizures
  • Muscle stiffness and difficulty in stretching the muscles, speech disorders, fainting, numbness or tingling (paresthesia), decreased sense of touch (hypoaesthesia), migraine, change in taste, memory loss
  • Changes in lacrimal secretion, constriction of the pupil, visual disturbances
  • Abnormally acute sense of hearing (hyperacusis) or dizziness (vertigo)
  • Accelerated heartbeat, hearing your own heartbeat
  • Widening of blood vessels (vasodilation)
  • Difficulty in breathing, cough, sore throat, runny nose, voice changes, respiratory depression
  • Difficulty swallowing, mouth ulcers, gingivitis, inflammation of the mouth (stomatitis), flatulence, belching, intestinal obstruction (ileus)
  • Increase in liver enzymes
  • skin dryness
  • difficulty urinating
  • sexual impotence
  • Pain (e.g. chest pain), chills, excess fluid in the tissues (oedema), feeling unwell, physical dependence with withdrawal symptoms, drug tolerance requiring higher dose to maintain effect, thirst
  • Injuries due to accidents

Rare side effects are listed below:

  • Herpes simplex (skin and mucous membrane disorder)
  • Lymph node disease (lymphadenopathy)
  • increased appetite
  • Low blood pressure, dizziness when standing up from a sitting or lying position
  • Bleeding gums, tarry stools, tooth staining and damage
  • Itchy skin rash (urticaria), increased sensitivity to light (photosensitivity)
  • muscle spasms
  • blood in the urine (hematuria)
  • Changes in body weight (decrease or increase), cellulite

Very rare side effects are listed below:

  • Crustacean rash (exfoliative dermatitis)

The list of side effects listed above is not a complete list.

Inform your doctor immediately if you experience any undesirable effects while using this medicine.

You can read this article to get information about Lipo Mino injection.

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