Toseina contains codeine phosphate hemihydrate.
This medicine is used for the symptomatic treatment of dry cough a(not accompanied by mucus) in adults and adolescents over 12 years of age.
What Will We Learn?
What You Should Know Before Taking Toseina
Do not use Toseina in the following situations:
- If you are allergic to codeine or any of the other ingredients of this drug.
- If you have breathing problems such as chronic obstructive pulmonary disease (COPD), respiratory depression (slow or insufficiently forceful breathing), or acute asthma attacks.
- If you have or are at risk of having paralytic ileus (intestinal obstruction)
- If you have diarrhea associated with pseudomembranous colitis (intestinal inflammation) or diarrhea caused by poisoning caused by antibiotic drugs (such as cephalosporins, lincomycins or penicillins).
- If you are under 12 years old.
- If you know you are metabolizing codeine to morphine very quickly.
- If you are pregnant or breastfeeding.
Talk to your doctor or pharmacist before taking toseina if you have the conditions listed below:
- If you have heart, lung, liver, gallbladder or kidney problems, as well as prostate disorders (prostatic hypertrophy), narrowing of the urethra (urethral stricture), obstructive or inflammatory bowel disorders, chronic ulcerative colitis, acute pancreatitis, hypothyroidism, multiple sclerosis.
- The elderly or debilitated people are generally more sensitive to the effects and side effects of this drug, especially respiratory depression.
- In the case of a strong blow to the head (skull trauma) and high pressure inside the brain (intracranial), codeine can increase the pressure of the cerebrospinal fluid, which can increase its respiratory suppressive effect (slow or insufficient breathing).
- Like other opioids, codeine can prevent bowel movement by worsening constipation in patients with chronic constipation.
Abuse and dependence: Prolonged and excessive administration of codeine can cause dependence and/or tolerance, especially in individuals with a tendency to abuse and dependence.
After long-term treatments, you should gradually discontinue the application as directed by your doctor.
This medicine should not be taken for more than three days. If there is no relief from the cough after three days, you should see your doctor.
Codeine is converted to morphine by an enzyme in the liver.
Morphine is a substance that creates the effect of codeine.
Some people have a variant of this enzyme that may affect them differently.
Some people do not produce morphine or are produced in very low amounts and have no effect on your cough symptoms.
Other people are more prone to serious side effects because they produce very high amounts of morphine.
Other Drugs And Toseina
Tell your doctor or pharmacist if you are taking or have recently taken any other medicines.
In particular, if you are using any of the following medicines, you may need to change the dose of any of them or stop treatment:
- Narcotic analgesics (for pain), antipsychotics (tranquilizers), anxiolytics (for anxiety), neuromuscular blockers (drugs used to facilitate mechanical ventilation), and other central nervous system depressants (including alcohol)
- Alcohol-containing drugs should be avoided during treatment.
- Buprenorphine (pain reliever) and naltrexone (medication used to treat acute codeine, morphine, heroin and alcohol intoxication)
- Anticholinergics (drugs that reduce the effects of acetylcholine)
- MAO inhibitors (medicines used to treat depression or Parkinson’s disease) or tricyclic antidepressants
- Hydroxyzine (allergy medicine)
- Certain phenothiazines (drugs used to treat nervous, mental, and emotional disorders, also used to control very severe nausea and vomiting)
- Antidiarrheal agents that prevent bowel movement.
Avoid drinking alcoholic beverages, as alcohol potentiates the central nervous system depressant effect of codeine.
This medicine contains codeine, which may cause a positive result in doping control tests.
Pregnancy, Lactation And Fertility
If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, talk to your doctor or pharmacist before using this medicine.
Do not take Toseina during pregnancy.
Do not take codeine if you are breastfeeding.
Codeine and morphine pass into breast milk.
How To Take Toseina?
Follow the instructions given by your doctor or pharmacist for the use of this medicine.
In case of doubt, consult your doctor or pharmacist again.
Doses should be individualized for each patient.
The lowest effective dose should be used to control symptoms. The dose may be divided into up to 4 daily doses administered at intervals of at least 6 hours.
Administration of the drug is dependent on the occurrence of symptoms, and the dose may be reduced as symptoms disappear.
The duration of treatment should be limited to 3 days.
Adults and adolescents over 12 years of age: 10 to 20 mg of codeine (5 to 10 ml) at intervals of at least 6 hours.
Toseina is contraindicated in children under 12 years of age.
The dose will be determined by the doctor, as the elderly may require lower doses or longer dosing intervals.
To open the bottle, remove the dosing cup, press the cap down and turn it in the direction indicated by the arrows as shown in the drawing on the cap.
The bottle should be closed after each use.
Accidental ingestion of very high doses may initially cause excitement, anxiety, insomnia, and then drowsiness, headache, miosis, blood pressure changes, arrhythmias, dry mouth, hypersensitivity reactions, cold and clammy skin, tachycardia, seizures, gastrointestinal disorders, nausea, vomiting and respiratory depression.
In severe poisoning, apnea, circulatory collapse, cardiac arrest and death may occur.
If you think you have taken too much of a dose, call the emergency room immediately.
Do not take a double dose to make up for a forgotten dose.
Side Effects Of Toseina
If you experience any of the following side effects, you should stop taking this medicine and seek medical attention immediately:
- Slow or shallow breathing
- Constricted pupils
- Sick or feeling unwell
- Loss of appetite
- Altered mood (happy or sad)
- Skin rashes
You may also notice our article on Torsilax, which is used in the treatment of colds.